EPHA2/3/4 anticorps

N° du produit ABIN6298589

L’anticorps Lapin Polyclonal anti-EPHA2/3/4 a été validé pour . Il convient pour détecter EPHA2/3/4 dans des échantillons de Humain et Rat.

Aperçu rapide pour EPHA2/3/4 anticorps (ABIN6298589)

Antigène: EPHA2/3/4 (EPH Receptor A2/3/4 (EPHA2/3/4))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPHA2/3/4 est non-conjugé

Application: Veuillez nous consulter SVP

Détail du produit anti-EPHA2/3/4 anticorps

Fonction: Rabbit Anti-EPHA2/3/4 (Ab-588/596) Antibody,

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur EPHA2/3/4

Antigène: EPHA2/3/4 (EPH Receptor A2/3/4 (EPHA2/3/4))

Autre désignation: EPHA2/3/4

Sujet:

Target Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Gene Symbol: EPHA2

ID gène: 1969

UniProt: P29317